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•   Engineering Biomaterials for Immunomodulation

•   Targeted Drug Delivery and Nanodiagnostics

LATEST NEWS

Current News

August 13, 2014: Immune cells get cancer-fighting boost from nanomaterials

July 2014: Tarek Fahmy named one of the top five translational junior faculty in 2013 by Bioentrepreneur, a publication of Nature Biotechnology.

March 2013: Nanogels offer new way to attack lupus

July 15, 2012: Nanoparticles that deliver a combination of factors: activating immunity in the tumor microenvironment.

May 2012: Michael Look wins the 2012 SEAS Harding Bliss Prize, which is awarded to the graduating doctoral student who has done the most to further the intellectual life of the department.

April 2012: Fiona Sharp wins the Browne-Cox Postdoctoral fellowship for, "Engineering Artificial Antigen-presenting cells as new vaccines"

February 2012: Jason Criscione successfully defened "Designing Dendrimer-based Nanosystems for Multimodal Imaging and Theranostic Applications" (Feb. 2. 2012)

June 2011: Fiona Sharp won the Blue Ribbon prize at this year's FOCIS meeting (Federation of the Clinical Immunology Societies). Her poster title, "Biodegradable Artificial Antigen-Presenting cells with Paracrine IL-2 delivery."

5/18/2011: Tarek Fadel was awarded the 2011 Harding Bliss Prize by the Yale School of Engineering and Applied Science. This prize is presented annually to a graduating student who has done the most to further the intellectual life within the School. more...

4/5/2011: Alyssa Siefert was awarded an Honorable Mention in this year's National Science Foundation Graduate Research Fellowship Program.

3/5/2011: Enping Hong wins Best Poster Presentation by a Student at the Human Translational Immunology retreat at Yale University.

Click for the StoryScientists Use Nanosensors for First Time to Measure Cancer Biomarkers in Blood

click for the story

Scientists Guide Immune Cells with Light and Microparticles



Two Researchers Will Develop New Therapy with Grant from Lupus Research Institute

Fahmy Lab receives the Wallace Coulter Foundation Award

Sensitive Nanowires disease detector by Yale Scientists.

Breakthrough in nanodevice synthesis revolutionizes biological sensors.

Yale Scientists Create Artificial "Cells" that Boost the Immune Response.

Tiny disease detector is like a lab on a chip

Yale receives $1-million grant to develop "smart nanoparticles" for the delivery of vaccines.

Download all Fahmy Lab publications here!

Just Published

Fadel TR, Sharp FA, Vudattu N, Ragheb R, Garyu J, Kim D, Hong E, Li N, Haller GL, Pfefferle LD, Justesen S, Herold KC, Fahmy TM. A carbon nanotube-polymer composite for T-cell therapy. Nature Nanotechnology. Published online 3 August 2014.

Seghal K, Ragheb R, Fahmy TM, Dhodapkar MV, Dhodapkar KM. Nanoparticle-mediated targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. J Immunol. 30 June 2014.

Nanogels for treatment of Lupus

illustration

Nanoparticles (white spheres) are loaded with a toxic drug, mycophenolic acid (yellow-green molecule), and treat disease (in mice) with greater potency and less toxicity than conventional regimens that do not use nanoparticles. The particles are engulfed by dendritic cells (violet cell on the left) or bind CD4 T cells (purple cell on the right). These immune cells are acutely affected by nanotherapy because of the particles’ unique homing ability. This nanoparticle system may hold promise in providing new therapeutic strategies for lupus patients and others with autoimmune disease. Illustration by Nicolle R. Fuller, Sayo-Art LLC, 2013.

Look M, Stern E, Wang Q, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM. Nanogel-based particles for treatment of systemic lupus erythematosus. J. Clin. Invest. March 1, 2013.

Ragheb and Kim et. al. Clustered Nanoconfinement enhances Imaging Modality.

Ragheb figure

Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics.
Ragheb RR, Kim D, Bandyopadhyay A, Chahboune H, Bulutoglu B, Ezeldein H, Criscione JM, Fahmy TM. Magn Reson Med. 2013 Feb 7.

Dong et. al . Immuno-isolation of pancreatic islet allografts using pegylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice.

Fadel et. al. Adsorption of Multimeric T Cell Antigens on Carbon Nanotubes: Effect on Protein Structure and Antigen-Specific T Cell Stimulation.

Carbon nanotube bundles coupled to peptide/MHC
for activation of antigen-specific lymphocyte.

Park, et. al. Combination Delivery of TGF-b inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumor immunotherapy. Nature Materials. Published online. July 15. www.nature.com

Combination delivery of factors that activate immunity around a tumor and at the same time inhibit the tumor's ability to suppress the immune response. Nanoscale vehicles shown composed of biodegradable polymers and cyclodextrin enclosed in a lipid shell are entrapped in tumor vasculature and release TGF-b inhibitors (blue) and IL-2 cytokine (green)

Corradetti B, et. al. Paracrine signalling events in embryonic stem cell renewal mediated by affinity targeted nanoparticles. Biomaterials. 2012 Jun 30. [Epub ahead of print]

stem cell

Demento et. al. Role of Sustained Antigen Release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 2012 Jun;33(19):4957-64. Epub 2012 Apr 6.

Role of Sustained Antigen Release...

Labowsky and Fahmy. Modeling of Paracrine Delivery from a particle or cell to another cell Chem. Eng. Sci. 74 (2012) 114-123.
image

Steenblock et. al : An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response. J Biol Chem. 2011 Aug 17. [Epub ahead of print] [Pubmed]
diagram

Crisione et. al : Development and application of a multimodal contrast agent for SPECT/CT hybrid imaging. Bioconjug Chem. 2011 Aug 18. [Epub ahead of print] [Pubmed]
diagram

Look et. al Nanoparticle Delivery of Mycophenolic Acid Upregulates PD-L1 on Dendritic Cells to Prolong Murine Allograft Survival. Am J Transplant. 2011 Aug 30. [Epub ahead of print] [Pubmed]

Park et. al "Modulation of CD4+ T Lymphocyte Lineage Outcomes with Targeted, Nanoparticle-Mediated Cytokine Delivery." Molecular Pharamceutics, 2010"
diagram

Bandyopadhyay A, et al. "The impact of nanoparticle ligand density on dendritic-cell targeted vaccines." Biomaterials, 2011
pub diagram

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Yale University Dept. of Biomedical Engineering Dept. of Chemical Engineering