Nanogels for treatment of Lupus
Nanoparticles (white spheres) are loaded with a toxic drug, mycophenolic acid (yellow-green molecule), and treat disease (in mice) with greater potency and less toxicity than conventional regimens that do not use nanoparticles. The particles are engulfed by dendritic cells (violet cell on the left) or bind CD4 T cells (purple cell on the right). These immune cells are acutely affected by nanotherapy because of the particles’ unique homing ability. This nanoparticle system may hold promise in providing new therapeutic strategies for lupus patients and others with autoimmune disease. Illustration by Nicolle R. Fuller, Sayo-Art LLC, 2013.
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Carbon nanotube bundles coupled to peptide/MHC
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Combination delivery of factors that activate immunity around a tumor and at the same time inhibit the tumor's ability to suppress the immune response. Nanoscale vehicles shown composed of biodegradable polymers and cyclodextrin enclosed in a lipid shell are entrapped in tumor vasculature and release TGF-b inhibitors (blue) and IL-2 cytokine (green)
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