Fadel TR, Sharp FA, Vudattu N, Ragheb R, Garyu J, Kim D, Hong E, Li N, Haller GL, Pfefferle LD, Justesen S, Herold KC, Fahmy TM. A carbon nanotube-polymer composite for T-cell therapy. Nature Nanotechnology. Published online 3 August 2014.
Seghal K, Ragheb R, Fahmy TM, Dhodapkar MV, Dhodapkar KM. Nanoparticle-mediated targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. J Immunol. 30 June 2014.
Nanogels for treatment of Lupus
Nanoparticles (white spheres) are loaded with a toxic drug, mycophenolic acid (yellow-green molecule), and treat disease (in mice) with greater potency and less toxicity than conventional regimens that do not use nanoparticles. The particles are engulfed by dendritic cells (violet cell on the left) or bind CD4 T cells (purple cell on the right). These immune cells are acutely affected by nanotherapy because of the particles’ unique homing ability. This nanoparticle system may hold promise in providing new therapeutic strategies for lupus patients and others with autoimmune disease. Illustration by Nicolle R. Fuller, Sayo-Art LLC, 2013.
Look M, Stern E, Wang Q, DiPlacido LD, Kashgarian M, Craft J, Fahmy TM. Nanogel-based particles for treatment of systemic lupus erythematosus. J. Clin. Invest. March 1, 2013.
Ragheb and Kim et. al. Clustered Nanoconfinement enhances Imaging Modality.
Induced clustered nanoconfinement of superparamagnetic iron oxide in biodegradable nanoparticles enhances transverse relaxivity for targeted theranostics.
Ragheb RR, Kim D, Bandyopadhyay A, Chahboune H, Bulutoglu B, Ezeldein H, Criscione JM, Fahmy TM. Magn Reson Med. 2013 Feb 7.
Dong et. al . Immuno-isolation of pancreatic islet allografts using pegylated nanotherapy leads to long-term normoglycemia in full MHC mismatch recipient mice.
Fadel et. al. Adsorption of Multimeric T Cell Antigens on Carbon Nanotubes: Effect on Protein Structure and Antigen-Specific T Cell Stimulation.
Carbon nanotube bundles coupled to peptide/MHC
for activation of antigen-specific lymphocyte.
Park, et. al. Combination Delivery of TGF-b inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumor immunotherapy. Nature Materials. Published online. July 15. www.nature.com
Combination delivery of factors that activate immunity around a tumor and at the same time inhibit the tumor's ability to suppress the immune response. Nanoscale vehicles shown composed of biodegradable polymers and cyclodextrin enclosed in a lipid shell are entrapped in tumor vasculature and release TGF-b inhibitors (blue) and IL-2 cytokine (green)
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Demento et. al. Role of Sustained Antigen Release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials. 2012 Jun;33(19):4957-64. Epub 2012 Apr 6.
Labowsky and Fahmy. Modeling of Paracrine Delivery from a particle or cell to another cell Chem. Eng. Sci. 74 (2012) 114-123.
Steenblock et. al : An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response. J Biol Chem. 2011 Aug 17. [Epub ahead of print] [Pubmed]
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Bandyopadhyay A, et al. "The impact of nanoparticle ligand density on dendritic-cell targeted vaccines." Biomaterials, 2011